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Structural biology of the Atg8 and Atg12 conjugation systems

10 Nov 2023

Abstract excerpt

Atg8 and Atg12 are ubiquitin-like proteins, conjugated to phosphatidylethanolamine (PE) and Atg5, respectively, through enzymatic reactions similar to ubiquitylation. The resultant Atg8-PE and Atg12-Atg5 conjugates play crucial roles in autophagy. Structural studies have been extensively performed on all Atg proteins (Atg3, Atg4, Atg5, Atg7, Atg8, Atg10, Atg12, Atg16) involved in these conjugation systems. This...

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PMID: 40395304
DOI: 10.1080/27694127.2023.2277582

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