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Article

An Atg4B mutant hampers the lipidation of LC3 paralogues and causes defects in autophagosome closure.

Molecular biology of the cell - 1 Nov 2008

Fujita Naonobu, Hayashi-Nishino Mitsuko, Fukumoto Hiromi, Omori Hiroko, Yamamoto Akitsugu, Noda Takeshi, Yoshimori Tamotsu

Abstract excerpt

In the process of autophagy, a ubiquitin-like molecule, LC3/Atg8, is conjugated to phosphatidylethanolamine (PE) and associates with forming autophagosomes. In mammalian cells, the existence of multiple Atg8 homologues (referred to as LC3 paralogues) has hampered genetic analysis of the lipidatio...

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Source

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Identifiers

PMID: 18768752
DOI: 10.1091/mbc.e08-03-0312
PMCID: PMC2575160

Genes

ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18768752-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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