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Article

Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model.

Genes & development - 1 Apr 2016

Chen Song, Wang Chenran, Yeo Syn, Liang Chun-Chi, Okamoto Takako, Sun Shaogang, Wen Jian, Guan Jun-Lin

Abstract excerpt

Autophagy is an evolutionarily conserved cellular process controlled through a set of essential autophagy genes (Atgs). However, there is increasing evidence that most, if not all, Atgs also possess functions independent of their requirement in canonical autophagy, making it difficult to distinguish the contributions of autophagy-dependent or -independent functions of a particular Atg to various biological...

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Identifiers

PMID: 27013233
DOI: 10.1101/gad.276428.115
PMCID: PMC4826400

Genes

ULK1

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