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Article

Folate and MTHFR: risk of adenoma recurrence in the Polyp Prevention Trial.

Cancer causes & control : CCC - 1 Sept 2008

Murphy Gwen, Sansbury Leah B, Cross Amanda J, Stolzenberg-Solomon Rachael, Laiyemo Adeyinka, Albert Paul S, Wang Zhuoqiao, Schatzkin Arthur, Lehman Teresa, Kalidindi Aravind, Modali Rama, Lanza Elaine

Abstract excerpt

BACKGROUND: Low dietary folate intake has been associated with colorectal cancer risk and adenoma recurrence. A C/T transition at position 677 in the gene encoding methlylenetetrahydrofolate reductase (MTHFR C677T) has been reported to interact with folate intake to modulate colorectal adenoma recurrence or cancer risk. METHODS: We investigated the association between MTHFR, total folate, and the risk of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18322814
DOI: 10.1007/s10552-008-9137-6

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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