Article
Dietary factors and biomarkers involved in the methylenetetrahydrofolate reductase genotype-colorectal adenoma pathway.
Gastroenterology - 1 Dec 2006
Martínez María Elena, Thompson Patricia, Jacobs Elizabeth T, Giovannucci Edward, Jiang Ruiyun, Klimecki Walt, Alberts David S
Abstract excerpt
BACKGROUND & AIMS: Methylenetetrahydrofolate reductase (MTHFR) is involved in intracellular folate homeostasis and metabolism. We assessed 2 polymorphisms in the MTHFR gene (C677T and A1298C) in relation to colorectal adenoma recurrence and conducted analyses to investigate their joint effects with plasma and dietary markers of folate status. METHODS: We prospectively analyzed data from 1598 individuals genotyped...
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