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Article

A role for Pak protein kinases in Schwann cell transformation

28 Apr 1998

Abstract excerpt

Neurofibromatosis type 1 (NF1), a common autosomal dominant disorder caused by loss of the NF1 gene, is characterized clinically by neurofibromas and more rarely by neurofibrosarcomas. Neurofibromin, the protein encoded by NF1, possesses an intrinsic GTPase accelerating activity for the Ras proto-oncogene. Through this activity, it is a negative regulator of Ras. The Pak protein kinase is a candidate for a...

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PMID: 9560242
DOI: 10.1073/pnas.95.9.5139

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