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Article

High resolution array-comparative genomic hybridization profiling reveals deoxyribonucleic acid copy number alterations associated with medullary thyroid carcinoma.

The Journal of clinical endocrinology and metabolism - 1 Nov 2008

Ye Lei, Santarpia Libero, Cote Gilbert J, El-Naggar Adel K, Gagel Robert F

Abstract excerpt

CONTEXT: Activating mutations in the RET protooncogene have been demonstrated in multiple endocrine neoplasia 2 and sporadic medullary thyroid carcinoma (MTC). However, the complete genetic etiology underlying MTC tumorigenesis remains unclear. OBJECTIVE: Our objective was to define more precisely the chromosomal regions and uncover novel genes associated with MTC tumorigenesis. DESIGN AND SETTING: In this study,...

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Topics

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Share to Chromosome Aberrations
Share to Chromosomes, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Comparative Genomic Hybridization

Share to DNA, Neoplasm

Share to Genes, Suppressor

Share to Proto-Oncogene Proteins c-ret

Share to Sensitivity and Specificity

Share to Thyroid Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 18765511
DOI: 10.1210/jc.2008-0912
PMCID: PMC2729231

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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