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Article

RET Copy Number Alteration in Medullary Thyroid Cancer Is a Rare Event Correlated with RET Somatic Mutations and High Allelic Frequency.

Genes - 29 Dec 2020

Ramone Teresa, Mulè Chiara, Ciampi Raffaele, Bottici Valeria, Cappagli Virginia, Prete Alessandro, Matrone Antonio, Piaggi Paolo, Torregrossa Liborio, Basolo Fulvio, Elisei Rossella, Romei Cristina

Abstract excerpt

Copy number variations (CNV) of the RET gene have been described in 30% of Medullary Thyroid Cancer (MTC), but no information is available about their role in this tumor. This study was designed to clarify RET gene CNV prevalence and their potential role in MTC development. RET gene CNV were analyzed in 158 sporadic MTC cases using the ION Reporter Software (i.e., in silico analysis) while the multiplex...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Recurrence, Local

Share to Proto-Oncogene Proteins c-ret

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Source

Open in PubMed Open full text

Identifiers

PMID: 33383911
DOI: 10.3390/genes12010035
PMCID: PMC7824333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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