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Article

Role of CDKN2C Copy Number in Sporadic Medullary Thyroid Carcinoma.

Thyroid : official journal of the American Thyroid Association - 1 Nov 2016

Grubbs Elizabeth G, Williams Michelle D, Scheet Paul, Vattathil Selina, Perrier Nancy D, Lee Jeffrey E, Gagel Robert F, Hai Tao, Feng Lei, Cabanillas Maria E, Cote Gilbert J

Abstract excerpt

BACKGROUND: The cyclin-dependent-kinase inhibitors (CDKN)/retinoblastoma (RB1) pathway has been implicated as having a role in medullary thyroid carcinoma (MTC) tumorigenesis. CDKN2C loss has been associated with RET-mediated MTC in humans but with minimal phenotypic correlation provided. The objective of this study was to evaluate the association between tumor RET mutation status, CDKN2C loss, and aggressiveness...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p18

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Source

Open in PubMed Open full text

Identifiers

PMID: 27610696
DOI: 10.1089/thy.2016.0224
PMCID: PMC6453497

Genes

RET

Provenance

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