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Article

A composite-conditional-likelihood approach for gene mapping based on linkage disequilibrium in windows of marker loci.

Statistical applications in genetics and molecular biology - 1 Jan 2008

Larribe Fabrice, Lessard Sabin

Abstract excerpt

A composite-conditional-likelihood (CCL) approach is proposed to map the position of a trait-influencing mutation (TIM) using the ancestral recombination graph (ARG) and importance sampling to reconstruct the genealogy of DNA sequences with respect to windows of marker loci and predict the linkage disequilibrium pattern observed in a sample of cases and controls. The method is designed to fine-map the location of...

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PMID: 18764776
DOI: 10.2202/1544-6115.1298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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