A general conditional-logistic model for affected-relative-pair linkage studies.

Abstract excerpt

Model-free LOD-score methods are often employed to detect linkage between marker loci and common diseases, with samples of affected sib pairs. Although extensions of the basic one-disease-locus model have been proposed that allow separate inclusion of other types of affected relative pairs, discordant relative pairs, covariates, or additional disease loci, a unified framework that can handle all of these features...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computer Simulation
• Share to Diabetes Mellitus, Type 1
• Share to Ethnicity