A general conditional-logistic model for affected-relative-pair linkage studies.

doi:10.1086/302662

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Article

A general conditional-logistic model for affected-relative-pair linkage studies.

American journal of human genetics - 1 Dec 1999

Olson J M

Abstract excerpt

Model-free LOD-score methods are often employed to detect linkage between marker loci and common diseases, with samples of affected sib pairs. Although extensions of the basic one-disease-locus model have been proposed that allow separate inclusion of other types of affected relative pairs, discordant relative pairs, covariates, or additional disease loci, a unified framework that can handle all of these features...

Topics

Alleles
Computer Simulation
Diabetes Mellitus, Type 1
Ethnicity
Gene Frequency
Genetic Linkage
Genetic Predisposition to Disease
Humans
Lod Score
Logistic Models
Models, Genetic
Sample Size

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Identifiers

PMID: 10577930
DOI: 10.1086/302662
PMCID: PMC1288403

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