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Article

In silico analysis of disease-association mapping strategies using the coalescent process and incorporating ascertainment and selection.

American journal of human genetics - 1 Jun 2005

Wang Ying, Rannala Bruce

Abstract excerpt

We present a new method for simulating samples of marker haplotypes, genotypes, or diplotypes in case-control studies in which the markers are linked to a disease locus in any specified region of the genome. The method allows realistic features to be incorporated into the simulations, including selection acting on disease alleles, sample ascertainment of disease chromosomes and polymorphic markers, a genetic...

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PMID: 15818531
DOI: 10.1086/430472
PMCID: PMC1196444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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