Article
Gene mapping via the ancestral recombination graph.
Theoretical population biology - 1 Sept 2002
Larribe Fabrice, Lessard Sabin, Schork Nicholas J
Abstract excerpt
We present a multilocus gene mapping method based on linkage disequilibrium, which uses the ancestral recombination graph to model the history of sequences that may harbor an influential variant. We describe the construction of a recurrence equation used to make inferences about the location of a trait-influencing mutation. We demonstrate how a Monte Carlo algorithm combined with a local importance sampling...
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