Article
Matrix metalloproteinase-2 gene variants and abdominal aortic aneurysm.
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery - 1 Aug 2009
Smallwood L, Warrington N, Allcock R, van Bockxmeer F, Palmer L J, Iacopetta B, Golledge J, Norman P E
Abstract excerpt
OBJECTIVE: To investigate associations between two polymorphisms of the matrix metalloproteinase-2 gene (MMP2) and the incidence and progression of abdominal aortic aneurysm (AAA). METHODS: Cases and controls were recruited from a trial of screening for AAAs. The association between two variants of MMP2 (-1360C>T, and +649C>T) in men with AAA (n=678) and in controls (n=659) was examined using multivariate...
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