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Article

Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses.

Archives of general psychiatry - 1 Sept 2008

Kamiya Atsushi, Tan Perciliz L, Kubo Ken-ichiro, Engelhard Caitlin, Ishizuka Koko, Kubo Akiharu, Tsukita Sachiko, Pulver Ann E, Nakajima Kazunori, Cascella Nicola G, Katsanis Nicholas, Sawa Akira

Abstract excerpt

CONTEXT: A role for the centrosome has been suggested in the pathology of major mental illnesses, especially schizophrenia (SZ). OBJECTIVES: To show that pericentriolar material 1 protein (PCM1) forms a complex at the centrosome with disrupted-in-schizophrenia 1 (DISC1) and Bardet-Biedl syndrome 4 protein (BBS4), which provides a crucial pathway for cortical development associated with the pathology of SZ. To...

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Source

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Identifiers

PMID: 18762586
DOI: 10.1001/archpsyc.65.9.996
PMCID: PMC2727928

Genes

PCM1
DISC1
BBS4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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