Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.

Nature genetics - 1 May 2004

Kim Jun Chul, Badano Jose L, Sibold Sonja, Esmail Muneer A, Hill Josephine, Hoskins Bethan E, Leitch Carmen C, Venner Kerrie, Ansley Stephen J, Ross Alison J, Leroux Michel R, Katsanis Nicholas, Beales Philip L

Abstract excerpt

BBS4 is one of several proteins that cause Bardet-Biedl syndrome (BBS), a multisystemic disorder of genetic and clinical complexity. Here we show that BBS4 localizes to the centriolar satellites of centrosomes and basal bodies of primary cilia, where it functions as an adaptor of the p150(glued) subunit of the dynein transport machinery to recruit PCM1 (pericentriolar material 1 protein) and its associated cargo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens
Share to Bardet-Biedl Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Centrosome

Share to Dyneins

Share to In Situ Nick-End Labeling

Share to Microtubule-Associated Proteins

Share to Microtubules

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 15107855
DOI: 10.1038/ng1352

Genes

BBS4
PCM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Bardet-Biedl protein BBS4 targets cargo to the pericentriolar region and is required for microtubule anchoring and cell cycle progression.PMID 15107855Read ↗

Bardet-Biedl Syndrome 1 Mutations Differentially Impact BBSome Integrity and its Function in Ciliary TraffickingSemantic proximity Read ↗

The BBSome assembly is spatially controlled by BBS1 and BBS4 in human cellsSemantic proximity Read ↗

Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes.Semantic proximity Read ↗

The BBSome assembly is spatially controlled by BBS1 and BBS4 in human cells.Semantic proximity Read ↗

The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.Semantic proximity Read ↗

A mouse model of BBS identifies developmental and homeostatic effects of BBS5 mutation and identifies novel pituitary abnormalities.Semantic proximity Read ↗

A <i>Bbs5</i> mouse model reveals pituitary cilia contributions to developmental abnormalitiesSemantic proximity Read ↗

Kinesin 1 regulates cilia length through an interaction with the Bardet-Biedl syndrome related protein CCDC28B.Semantic proximity Read ↗

Bardet-Biedl syndrome: Is it only cilia dysfunction?Semantic proximity Read ↗

BBS mutations modify phenotypic expression of CEP290-related ciliopathies.Semantic proximity Read ↗

Exome sequencing of Bardet-Biedl syndrome patient identifies a null mutation in the BBSome subunit BBIP1 (BBS18).Semantic proximity Read ↗

Molecular Architecture of the Bardet-Biedl Syndrome Protein 2-7-9 SubcomplexSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.