Article
No association between the PCM1 gene and schizophrenia: a multi-center case-control study and a meta-analysis.
Schizophrenia research - 1 Jun 2011
Hashimoto Ryota, Ohi Kazutaka, Yasuda Yuka, Fukumoto Motoyuki, Yamamori Hidenaga, Kamino Kouzin, Morihara Takashi, Iwase Masao, Kazui Hiroaki, Numata Shusuke, Ikeda Masashi, Ueno Shu-Ichi, Ohmori Tetsuro, Iwata Nakao, Ozaki Norio, Takeda Masatoshi
Abstract excerpt
Alterations in centrosomal function have been suggested in the pathology of schizophrenia. The molecule pericentriolar material 1 (PCM1) is involved in maintaining centrosome integrity and in the regulation of the microtubule cytoskeleton. PCM1 forms a complex at the centrosome with the disrupted-in-schizophrenia 1 (DISC1) protein, which is a major susceptibility factor for schizophrenia. The association between...
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