PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.

doi:10.1038/s41467-020-19637-5

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Article

PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.

Nature communications - 19 Nov 2020

Monroe Tanner O, Garrett Melanie E, Kousi Maria, Rodriguiz Ramona M, Moon Sungjin, Bai Yushi, Brodar Steven C, Soldano Karen L, Savage Jeremiah, Hansen Thomas F, Muzny Donna M, Gibbs Richard A, Barak Lawrence, Sullivan Patrick F, Ashley-Koch Allison E, Sawa Akira, Wetsel William C, Werge Thomas, Katsanis Nicholas

Abstract excerpt

The neuronal primary cilium and centriolar satellites have functions in neurogenesis, but little is known about their roles in the postnatal brain. We show that ablation of pericentriolar material 1 in the mouse leads to progressive ciliary, anatomical, psychomotor, and cognitive abnormalities. RNAseq reveals changes in amine- and G-protein coupled receptor pathways. The physiological relevance of this phenotype...

Topics

Adult
Aged
Alleles
Amines
Animals
Antipsychotic Agents
Brain
Cell Cycle Proteins
Cilia
Drug Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Humans

Mice

Mice, Knockout

Middle Aged

Mutation

Phenotype

Receptors, Dopamine D2

Source

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Identifiers

PMID: 33214552
DOI: 10.1038/s41467-020-19637-5
PMCID: PMC7677393

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