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Article

Does SLC39A8 Ala391Thr Confer Risk of Chronic Liver Disease?

Antioxidants & redox signaling - 1 Oct 2024

Seidelin Anne-Sofie, Nordestgaard Børge G, Tybjærg-Hansen Anne, Stender Stefan

Abstract excerpt

Manganese is an important cofactor for numerous biological processes, including defense against reactive oxygen species. A common genetic variant in the manganese transporter SLC39A8 (p.Ala391Thr) has been associated with lower blood levels of manganese and with increases in markers of liver cell damage. Whether the variant confers an increased risk of liver disease is unclear. We tested the association of this...

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Source

Identifiers

PMID: 38687342
DOI: 10.1089/ars.2024.0616

Genes

SLC39A8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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