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Article

The A736V TMPRSS6 polymorphism influences hepatic iron overload in nonalcoholic fatty liver disease.

PloS one - 1 Jan 2012

Valenti Luca, Rametta Raffaela, Dongiovanni Paola, Motta Benedetta M, Canavesi Elena, Pelusi Serena, Pulixi Edoardo A, Fracanzani Anna L, Fargion Silvia

Abstract excerpt

BACKGROUND & AIMS: Hepatic iron accumulation due to altered trafficking is frequent in patients with nonalcoholic fatty liver disease (NAFLD), and is associated with more severe liver damage and hepatocellular carcinoma. The p.Ala736Val TMPRSS6 variant influences iron metabolism regulating the transcription of the hepatic hormone hepcidin, but its role in the pathogenesis of iron overload disorders is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23144979
DOI: 10.1371/journal.pone.0048804
PMCID: PMC3489825

Genes

TMPRSS6
HFE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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