Article
The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus.
Arthritis and rheumatism - 1 Sept 2008
Kariuki Silvia N, Crow Mary K, Niewold Timothy B
Abstract excerpt
OBJECTIVE: The C1858T polymorphism in PTPN22 has been associated with the risk of systemic lupus erythematosus (SLE) as well as multiple other autoimmune diseases. We have previously shown that high serum interferon-alpha (IFNalpha) activity is a heritable risk factor for SLE. The aim of this study was to determine whether the PTPN22 risk variant may shift serum cytokine profiles to higher IFNalpha activity,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.