Increased frequency of the PTPN22W* variant in primary Sjogren's Syndrome: Association with low type I IFN scores.

doi:10.1016/j.clim.2016.10.015

Article

Increased frequency of the PTPN22W* variant in primary Sjogren's Syndrome: Association with low type I IFN scores.

Clinical immunology (Orlando, Fla.) - 1 Dec 2016

Vlachogiannis Nikolaos I, Nezos Adrianos, Tzioufas Athanasios G, Koutsilieris Michael, Moutsopoulos Haralampos M, Mavragani Clio P

Abstract excerpt

Recent data suggest the association of the autoimmune gene variant PTPN22W* with dampened type I Interferon (IFN) responses, seen in a subset of primary Sjogren's Syndrome (pSS) patients. We sought to explore the potential contribution of PTPN22W* in this setting. PTPN22W* was identified in DNA samples derived from 352 pSS patients and 482 healthy controls (HC). Type I IFN score was determined in available...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Increased frequency of the PTPN22W* variant in primary Sjogren's Syndrome: Association with low type I IFN scores.

Abstract excerpt

Topics

Related research