Article

Modeling of a negative feedback mechanism explains age-dependent genetic architecture in reproduction in domesticated <i>C. elegans</i> strains

2017-03-06

Abstract excerpt

<h4>ABSTRACT</h4> Most biological traits and common diseases have a strong but complex genetic basis, controlled by large numbers of genetic variants with small contributions to a trait or disease risk. The effect-size of most genetic variants is not absolute, but can depend on a number of factors including the age and genetic background of an organism. In order to understand the mechanisms that cause these chang...

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Literature Corpus work: c5612dda-1d32-5ada-af36-ed4ff2f790f6
DOI: 10.1101/114348

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