Lineage Tracing and Single-Cell RNA-seq in C. elegans to Analyze Transgenerational Epigenetic Phenotypes Inherited from Germ Cells.

doi:10.1007/978-1-0716-3259-8_3

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Article

Lineage Tracing and Single-Cell RNA-seq in C. elegans to Analyze Transgenerational Epigenetic Phenotypes Inherited from Germ Cells.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Rodriguez Juan D, Katz David J

Abstract excerpt

The last several years have seen an increasing number of examples of transgenerational epigenetic inheritance, in which phenotypes are inherited for three or more generations without changes to the underlying DNA sequence. One model system that has been particularly useful for studying transgenerational epigenetic inheritance is C. elegans. Their short generation time and hermaphroditic reproduction have allowed...

Topics

Animals
Caenorhabditis elegans
Epigenesis, Genetic
Single-Cell Gene Expression Analysis
Germ Cells
Phenotype
Inheritance Patterns

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Open in PubMed

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PMID: 37464235
DOI: 10.1007/978-1-0716-3259-8_3

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