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Article

Stable Heritable Germline Silencing Directs Somatic Silencing at an Endogenous Locus.

Molecular cell - 16 Feb 2017

Minkina Olga, Hunter Craig P

Abstract excerpt

The importance of transgenerationally inherited epigenetic states to organismal fitness remains unknown as well-documented examples are often not amenable to mechanistic analysis or rely on artificial reporter loci. Here we describe an induced silenced state at an endogenous locus that persists, at 100% transmission without selection, for up to 13 generations. This unusually persistent silencing enables a...

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Identifiers

PMID: 28212751
DOI: 10.1016/j.molcel.2017.01.034
PMCID: PMC5389115

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