Article
Activating mutations in human acute megakaryoblastic leukemia.
Blood - 15 Nov 2008
Malinge Sébastien, Ragu Christine, Della-Valle Veronique, Pisani Didier, Constantinescu Stefan N, Perez Christelle, Villeval Jean-Luc, Reinhardt Dirk, Landman-Parker Judith, Michaux Lucienne, Dastugue Nicole, Baruchel André, Vainchenker William, Bourquin Jean-Pierre, Penard-Lacronique Virginie, Bernard Olivier A
Abstract excerpt
Oncogenic activation of tyrosine kinase signaling pathway is recurrent in human leukemia. To gain insight into the oncogenic process leading to acute megakaryoblastic leukemia (AMKL), we performed sequence analyses of a subset of oncogenes known to be activated in human myeloid and myeloproliferative disorders. In a series of human AMKL samples from both Down syndrome and non-Down syndrome patients, mutations...
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