Article
Pediatric mastocytosis-associated KIT extracellular domain mutations exhibit different functional and signaling properties compared with KIT-phosphotransferase domain mutations.
Blood - 19 Aug 2010
Yang Ying, Létard Sébastien, Borge Laurence, Chaix Amandine, Hanssens Katia, Lopez Sophie, Vita Marina, Finetti Pascal, Birnbaum Daniel, Bertucci François, Gomez Sophie, de Sepulveda Paulo, Dubreuil Patrice
Abstract excerpt
Compared with adults, pediatric mastocytosis has a relatively favorable prognosis. Interestingly, a difference was also observed in the status of c-kit mutations according to the age of onset. Although most adult patients have a D(816)V mutation in phosphotransferase domain (PTD), we have describ...
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