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Article

KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3.

The Journal of biological chemistry - 31 Oct 2008

Huang Xiangwei, Li Xia, Guo Bin

Abstract excerpt

KLF6 (Kruppel-like factor 6) is a zinc finger transcription factor and a tumor suppressor that is frequently mutated in prostate cancer. KLF6 suppresses tumor growth and induces apoptosis in cancer cells through mechanisms still not defined. Here we show that KLF6 induces apoptosis in prostate cancer cells by ATF3 (activating transcription factor 3) expression. KLF6 binds directly to and activates the ATF3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18755691
DOI: 10.1074/jbc.M802515200
PMCID: PMC2573052

Genes

ATF3
KLF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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