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Article

Ubiquitin-specific protease 14 promotes prostate cancer progression through deubiquitinating the transcriptional factor ATF2.

Biochemical and biophysical research communications - 26 Mar 2020

Geng Lin, Chen Xing, Zhang Meng, Luo Zhenkai

Abstract excerpt

Activating Transcription Factor 2 (ATF2) is a member of the ATF/CREB bZIP family of transcription factors and an oncogene in prostate cancer. ATF2 has been reported to be a critical substrate of the CUL3-SPOP-RBX1 E3 ubiquitin ligase complex and the recurrent somatic mutation of SPOP has been believed to be a key feature of prostate cancer. However, the deubiquitinating enzyme required for ATF2 stabilization is...

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PMID: 31964530
DOI: 10.1016/j.bbrc.2019.12.128

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Ubiquitin-specific protease 14 promotes prostate cancer progression through deubiquitinating the transcriptional factor ATF2.PMID 31964530Read ↗

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