Article
TRPC4- and TRPC4-containing channels.
Handbook of experimental pharmacology - 1 Jan 2014
Freichel Marc, Tsvilovskyy Volodymyr, Camacho-Londoño Juan E
Abstract excerpt
TRPC4 proteins comprise six transmembrane domains, a putative pore-forming region, and an intracellularly located amino- and carboxy-terminus. Among eleven splice variants identified so far, TRPC4α and TRPC4β are the most abundantly expressed and functionally characterized. TRPC4 is expressed in various organs and cell types including the soma and dendrites of numerous types of neurons; the cardiovascular system...
Topics
- Amino Acid Sequence
- Animals
- Calcium Signaling
- Gene Expression Regulation
- Genotype
- Humans
- Membrane Potentials
- Membrane Transport Modulators
- Mice
- Mice, Knockout
- Molecular Sequence Data