Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.

doi:10.1016/s0092-8674(03)00716-5

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Article

Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors.

Cell - 19 Sept 2003

Yuan Joseph P, Kiselyov Kirill, Shin Dong Ming, Chen Jin, Shcheynikov Nikolay, Kang Shin H, Dehoff Marlin H, Schwarz Martin K, Seeburg Peter H, Muallem Shmuel, Worley Paul F

Abstract excerpt

Receptor signaling at the plasma membrane often releases calcium from intracellular stores. For example, inositol triphosphate (IP3) produced by receptor-coupled phospholipase C activates an intracellular store calcium channel, the IP(3)R. Conversely, stores can induce extracellular calcium to en...

Topics

Animals
Binding Sites
Brain
Calcium
Calcium Channels
Calcium Signaling
Carrier Proteins
Cell Membrane
Cells, Cultured
Homer Scaffolding Proteins
Inositol 1,4,5-Trisphosphate Receptors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ion Channel Gating

Macromolecular Substances

Membrane Potentials

Mice

Mice, Mutant Strains

Mutation

Neuropeptides

Source

Open in PubMed

Identifiers

PMID: 14505576
DOI: 10.1016/s0092-8674(03)00716-5

Genes

TRPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-14505576-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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