Article
Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.
The Journal of biological chemistry - 11 Jun 2010
Sammels Eva, Devogelaere Benoit, Mekahli Djalila, Bultynck Geert, Missiaen Ludwig, Parys Jan B, Cai Yiqiang, Somlo Stefan, De Smedt Humbert
Abstract excerpt
Autosomal dominant polycystic kidney disease is characterized by the loss-of-function of a signaling complex involving polycystin-1 and polycystin-2 (TRPP2, an ion channel of the TRP superfamily), resulting in a disturbance in intracellular Ca(2+) signaling. Here, we identified the molecular determinants of the interaction between TRPP2 and the inositol 1,4,5-trisphosphate receptor (IP(3)R), an intracellular...
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