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Article

In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46.

Journal of virology - 1 Nov 2008

Wang Hongjie, Liu Ying, Li Zongyi, Tuve Sebastian, Stone Daniel, Kalyushniy Oleksandr, Shayakhmetov Dmitry, Verlinde Christophe L M, Stehle Thilo, McVey John, Baker Andrew, Peng Kah-Whye, Roffler Steve, Lieber André

Abstract excerpt

Gene transfer vectors containing adenovirus (Ad) serotype 35 (Ad35) fibers have shown promise for cancer and stem cell gene therapy. In this study, we attempted to improve the in vitro and in vivo infection properties of these vectors by increasing their affinity to the Ad35 fiber receptor CD46. We constructed Ad vectors containing either the wild-type Ad35 fiber knob (Ad5/35) or Ad35 knob mutants with 4-fold-...

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Share to Adenoviridae
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18753195
DOI: 10.1128/JVI.01308-08
PMCID: PMC2573189

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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