Article

Targeting of immune cells by human adenoviruses: CD46 receptor density influences entry of chimaeric Ad5F35 into natural killer cells

2026-06-10

Abstract excerpt

Most adenovirus (Ad) vectors are based on the genome of human Ad type 5 (Ad5), which targets their entry to cells that express the Coxsackie and Adenovirus Receptor (CAR or CXADR). However, certain human Ads do not use CAR, for example Ad35 interacts with cell-surface CD46 and Ad3 uses desmoglein 2 (DSG2) for cell entry. In this study, a comparison of different Ad receptors using transcriptomic and proteomic datab...

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Literature Corpus work: 0178106d-0196-5b49-9bcc-4fe6850a7f62
DOI: 10.64898/2026.06.08.730800

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