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A New Group B Adenovirus Receptor Is Expressed at High Levels on Human Stem and Tumor Cells

27 Nov 2006

Abstract excerpt

CD46 is used by human group B adenoviruses (Ads) as a high-affinity attachment receptor. Here we show evidence that several group B Ads utilize an additional receptor for infection of human cells, which is different from CD46. We tentatively named this receptor receptor X. Competition studies with unlabeled and labeled Ads, recombinant Ad fiber knobs, and soluble CD46 and CD46 antibodies revealed three different...

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PMID: 17020944
DOI: 10.1128/jvi.01370-06

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