Article
Development and Assessment of Human Adenovirus Type 11 as a Gene Transfer Vector
28 Mar 2005
Abstract excerpt
Adenovirus vectors based on human serotype 5 (Ad5) have successfully been used as gene transfer vectors in many gene therapy-based approaches to treat disease. Despite their widespread application, many potential therapeutic applications are limited by the widespread prevalence of vector-neutralizing antibodies within the human population and the inability of Ad5-based vectors to transduce important therapeutic...
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