Article
A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.
Nature genetics - 1 Sept 2009
Song Honglin, Ramus Susan J, Tyrer Jonathan, Bolton Kelly L, Gentry-Maharaj Aleksandra, Wozniak Eva, Anton-Culver Hoda, Chang-Claude Jenny, Cramer Daniel W, DiCioccio Richard, Dörk Thilo, Goode Ellen L, Goodman Marc T, Schildkraut Joellen M, Sellers Thomas, Baglietto Laura, Beckmann Matthias W, Beesley Jonathan, Blaakaer Jan, Carney Michael E, Chanock Stephen, Chen Zhihua, Cunningham Julie M, Dicks Ed, Doherty Jennifer A, Dürst Matthias, Ekici Arif B, Fenstermacher David, Fridley Brooke L, Giles Graham, Gore Martin E, De Vivo Immaculata, Hillemanns Peter, Hogdall Claus, Hogdall Estrid, Iversen Edwin S, Jacobs Ian J, Jakubowska Anna, Li Dong, Lissowska Jolanta, Lubiński Jan, Lurie Galina, McGuire Valerie, McLaughlin John, Medrek Krzysztof, Moorman Patricia G, Moysich Kirsten, Narod Steven, Phelan Catherine, Pye Carole, Risch Harvey, Runnebaum Ingo B, Severi Gianluca, Southey Melissa, Stram Daniel O, Thiel Falk C, Terry Kathryn L, Tsai Ya-Yu, Tworoger Shelley S, Van Den Berg David J, Vierkant Robert A, Wang-Gohrke Shan, Webb Penelope M, Wilkens Lynne R, Wu Anna H, Yang Hannah, Brewster Wendy, Ziogas Argyrios, Houlston Richard, Tomlinson Ian, Whittemore Alice S, Rossing Mary Anne, Ponder Bruce A J, Pearce Celeste Leigh, Ness Roberta B, Menon Usha, Kjaer Susanne Krüger, Gronwald Jacek, Garcia-Closas Montserrat, Fasching Peter A, Easton Douglas F, Chenevix-Trench Georgia, Berchuck Andrew, Pharoah Paul D P, Gayther Simon A
Abstract excerpt
Epithelial ovarian cancer has a major heritable component, but the known susceptibility genes explain less than half the excess familial risk. We performed a genome-wide association study (GWAS) to identify common ovarian cancer susceptibility alleles. We evaluated 507,094 SNPs genotyped in 1,817 cases and 2,353 controls from the UK and approximately 2 million imputed SNPs. We genotyped the 22,790 top ranked SNPs...