Article
Refinement of the associations between risk of colorectal cancer and polymorphisms on chromosomes 1q41 and 12q13.13.
Human molecular genetics - 15 Feb 2012
Spain Sarah L, Carvajal-Carmona Luis G, Howarth Kimberley M, Jones Angela M, Su Zhan, Cazier Jean-Baptiste, Williams Jennet, Aaltonen Lauri A, Pharoah Paul, Kerr David J, Cheadle Jeremy, Li Li, Casey Graham, Vodicka Pavel, Sieber Oliver, Lipton Lara, Gibbs Peter, Martin Nicholas G, Montgomery Grant W, Young Joanne, Baird Paul N, Morreau Hans, van Wezel Tom, Ruiz-Ponte Clara, Fernandez-Rozadilla Ceres, Carracedo Angel, Castells Antoni, Castellvi-Bel Sergi, Dunlop Malcolm, Houlston Richard S, Tomlinson Ian P M
Abstract excerpt
In genome-wide association studies (GWASs) of colorectal cancer, we have identified two genomic regions in which pairs of tagging-single nucleotide polymorphisms (tagSNPs) are associated with disease; these comprise chromosomes 1q41 (rs6691170, rs6687758) and 12q13.13 (rs7163702, rs11169552). We investigated these regions further, aiming to determine whether they contain more than one independent association...