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Article

Spontaneous neural tube defects in splotch mice supplemented with selected micronutrients.

Toxicology and applied pharmacology - 15 May 2006

Wlodarczyk Bogdan J, Tang Louisa S, Triplett Aleata, Aleman Frank, Finnell Richard H

Abstract excerpt

Splotch (Sp/Sp) mice homozygous for a mutation in the Pax3 gene inevitably present with neural tube defects (NTDs), along with other associated congenital anomalies. The affected mutant embryos usually die by gestation days (E) 12-13. In the present study, the effect of modifier genes from a new genetic background (CXL-Sp) and periconceptional supplementation with selected micronutrients (folic acid,...

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Source

Identifiers

PMID: 16226775
DOI: 10.1016/j.taap.2005.09.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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