Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of folate supplementation on the risk of spontaneous and induced neural tube defects in Splotch mice.

Teratology - 1 Feb 2002

Gefrides Lisa A, Bennett Gregory D, Finnell Richard H

Abstract excerpt

BACKGROUND: Neural tube defects (NTDs) are among the most common human congenital malformations. Although clinical investigations have reported that periconceptional folic acid supplementation can reduce the occurrence of these defects, its mechanism remains unknown. Therefore, the murine mutant Splotch, which has a high incidence of spontaneous NTDs, along with the inbred strains SWV and LM/Bc, were used to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arsenates
Share to Embryo Loss
Share to Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leucovorin

Share to Neural Tube Defects

Share to Paired Box Transcription Factors

Share to PAX3 Transcription Factor

Share to Teratogens

Source

Identifiers

PMID: 11857507
DOI: 10.1002/tera.10019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of folate supplementation on the risk of spontaneous and induced neural tube defects in Splotch mice.PMID 11857507Read ↗

Spontaneous neural tube defects in splotch mice supplemented with selected micronutrients.Semantic proximity Read ↗

Understanding the causes and prevention of neural tube defects: Insights from the <i>splotch</i> mouse modelSemantic proximity Read ↗

Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function.Semantic proximity Read ↗

Embryonic folate metabolism and mouse neural tube defects.Semantic proximity Read ↗

Folic acid supplementation can adversely affect murine neural tube closure and embryonic survival.Semantic proximity Read ↗

Insights into prevention of human neural tube defects by folic acid arising from consideration of mouse mutantsSemantic proximity Read ↗

The genetic background of the curly tail strain confers susceptibility to folate-deficiency-induced exencephaly.Semantic proximity Read ↗

Mouse models of neural tube defects: Investigating preventive mechanismsSemantic proximity Read ↗

Genetic basis of susceptibility to environmentally induced neural tube defects.Semantic proximity Read ↗

Mechanistic insights into folate supplementation from Crooked tail and other NTD-prone mutant mice.Semantic proximity Read ↗

Teratogenic response to arsenite during neurulation: relative sensitivities of C57BL/6J and SWV/Fnn mice and impact of the splotch allele.Semantic proximity Read ↗

Splotch locus mouse mutants: models for neural tube defects and Waardenburg syndrome type I in humans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.