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Physiology of Folate and Vitamin B<sub>12</sub>in Health and Disease

1 Jun 2004

Abstract excerpt

Folate is a water-soluble B-vitamin and enzymatic cofactor that is necessary for the synthesis of purine and thymidine nucleotides and for the synthesis of methionine from homocysteine. Impairment of folate-mediated one-carbon metabolic pathways can result from B-vitamin deficiencies and/or single nucleotide polymorphisms, and increases risk for pathologies, including cancer and cardiovascular disease, and...

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PMID: 15298442
DOI: 10.1111/j.1753-4887.2004.tb00070.x

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