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Article

Functional conversion from HIV-1 Rev to HTLV-1 Rex by mutation.

Biochemical and biophysical research communications - 15 Aug 1991

Kubota S, Nosaka T, Furuta R, Maki M, Hatanaka M

Abstract excerpt

A nucleolar localizing rev gene mutant M10 of human immunodeficiency virus type 1 (HIV-1) lost a Rev function completely, instead, gained a Rex activity of human T cell leukemia virus type 1 (HTLV-1). The obtained compatibility between Rev M10 and Rex with their own nucleolar targeting signal (NOS) suggests a common molecular mechanism of their post-transcriptional regulation, despite no sequence similarities of...

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PMID: 1872842
DOI: 10.1016/0006-291x(91)91024-7

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Functional conversion from HIV-1 Rev to HTLV-1 Rex by mutation.PMID 1872842Read ↗

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Modulation of HTLV-I gene expression by HIV-1 Rev through an alternative RxRE-independent pathway mediated by the RU5 portion of the 5'-LTR.Semantic proximity Read ↗

The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements.Semantic proximity Read ↗

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Cytotoxic activity of rev protein of human immunodeficiency virus type 1 by nucleolar dysfunction.Semantic proximity Read ↗

Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function.Semantic proximity Read ↗

Regulation of the nucleocytoplasmic transport of HTLV-1 RNASemantic proximity Read ↗

Minimal Rev-response element for type 1 human immunodeficiency virus.Semantic proximity Read ↗

Resistance to RevM10 inhibition reflects a conformational switch in the HIV-1 Rev response element.Semantic proximity Read ↗

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