Functional conversion from HIV-1 Rev to HTLV-1 Rex by mutation.

doi:10.1016/0006-291x(91)91024-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Functional conversion from HIV-1 Rev to HTLV-1 Rex by mutation.

Biochemical and biophysical research communications - 15 Aug 1991

Kubota S, Nosaka T, Furuta R, Maki M, Hatanaka M

Abstract excerpt

A nucleolar localizing rev gene mutant M10 of human immunodeficiency virus type 1 (HIV-1) lost a Rev function completely, instead, gained a Rex activity of human T cell leukemia virus type 1 (HTLV-1). The obtained compatibility between Rev M10 and Rex with their own nucleolar targeting signal (NOS) suggests a common molecular mechanism of their post-transcriptional regulation, despite no sequence similarities of...

Topics

Amino Acid Sequence
Animals
Cell Line
Cell Nucleolus
Chloramphenicol O-Acetyltransferase
Cloning, Molecular
Gene Conversion
Gene Products, rev
Gene Products, rex
Genes, pX
Genes, rev

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

HIV-1

Human T-lymphotropic virus 1

Molecular Sequence Data

Mutation

Plasmids

Transfection

rev Gene Products, Human Immunodeficiency Virus

Source

Open in PubMed

Identifiers

PMID: 1872842
DOI: 10.1016/0006-291x(91)91024-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1872842-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional conversion from HIV-1 Rev to HTLV-1 Rex by mutation.PMID 1872842Read ↗

Effects of chimeric mutants of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex on nucleolar targeting signals.Semantic proximity Read ↗

HIV-1 Rev oligomerization is not obligatory in the presence of an extra basic domain.Semantic proximity Read ↗

Modulation of HTLV-I gene expression by HIV-1 Rev through an alternative RxRE-independent pathway mediated by the RU5 portion of the 5'-LTR.Semantic proximity Read ↗

The type I human T-cell leukemia virus (HTLV-I) Rex trans-activator binds directly to the HTLV-I Rex and the type 1 human immunodeficiency virus Rev RNA response elements.Semantic proximity Read ↗

Titration of cellular export factors, but not heteromultimerization, is the molecular mechanism of trans-dominant HTLV-1 rex mutants.Semantic proximity Read ↗

Cytotoxic activity of rev protein of human immunodeficiency virus type 1 by nucleolar dysfunction.Semantic proximity Read ↗

Transdominant repressors for human T-cell leukemia virus type I rex and human immunodeficiency virus type 1 rev function.Semantic proximity Read ↗

Regulation of the nucleocytoplasmic transport of HTLV-1 RNASemantic proximity Read ↗

Minimal Rev-response element for type 1 human immunodeficiency virus.Semantic proximity Read ↗

Resistance to RevM10 inhibition reflects a conformational switch in the HIV-1 Rev response element.Semantic proximity Read ↗

Binding of trans-dominant mutant Rev protein of human immunodeficiency virus type 1 to the cis-acting Rev-responsive element does not affect the fate of viral mRNA.Semantic proximity Read ↗

Mutational analysis of functional domains in the HIV-1 Rev trans-regulatory protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.