Article
Integrating genetic approaches into the discovery of anticancer drugs.
Science (New York, N.Y.) - 7 Nov 1997
Hartwell L H, Szankasi P, Roberts C J, Murray A W, Friend S H
Abstract excerpt
The discovery of anticancer drugs is now driven by the numerous molecular alterations identified in tumor cells over the past decade. To exploit these alterations, it is necessary to understand how they define a molecular context that allows increased sensitivity to particular compounds. Traditio...
Topics
- Animals
- Antineoplastic Agents
- Drug Design
- Drug Screening Assays, Antitumor
- Humans
- Mutation
- Neoplasms
- Signal Transduction
- Yeasts