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Article

Functional adhesiveness of the CX3CL1 chemokine requires its aggregation. Role of the transmembrane domain.

The Journal of biological chemistry - 31 Oct 2008

Hermand Patricia, Pincet Frédéric, Carvalho Stéphanie, Ansanay Hervé, Trinquet Eric, Daoudi Mehdi, Combadière Christophe, Deterre Philippe

Abstract excerpt

In its native form, the chemokine CX3CL1 is a firmly adhesive molecule promoting leukocyte adhesion and migration and hence involved, along with its unique receptor CX3CR1, in various inflammatory processes. Here we investigated the role of molecular aggregation in the CX3CL1 adhesiveness. Assays of bioluminescence resonance energy transfer (BRET) and homogeneous time-resolved fluorescence (HTRF) in transfected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18725411
DOI: 10.1074/jbc.M802638200
PMCID: PMC2662081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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