Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Concentration and proteolysis of CX3CL1 may regulate the microglial response to CX3CL1

15 Sept 2022

Abstract excerpt

Fractalkine (FKN) is a membrane-bound chemokine that can be cleaved by proteases such as ADAM 10, ADAM 17, and cathepsin S to generate soluble fragments. Studies using different forms of the soluble FKN yield conflicting results in vivo. These observations prompted us to investigate the function and pharmacology of two commonly used isoforms of FKN, a human full-length soluble FKN (sFKN), and a human chemokine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemokine receptors and signaling
Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Neuropeptides and Animal Physiology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36106533
DOI: 10.1002/glia.24269

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Concentration and proteolysis of CX3CL1 may regulate the microglial response to CX3CL1PMID 36106533Read ↗

Fractalkine in Health and DiseaseSemantic proximity Read ↗

The chemokine fractalkine can activate integrins without CX3CR1 through direct binding to a ligand-binding site distinct from the classical RGD-binding site.Semantic proximity Read ↗

Human induced pluripotent stem cell-derived microglia with a CX3CR1-V249I genetic variant exhibit dysfunctional phenotypes and modulate neuronal growth and functionSemantic proximity Read ↗

Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.Semantic proximity Read ↗

Anthocyanin effects on microglia M1/M2 phenotype: Consequence on neuronal fractalkine expression.Semantic proximity Read ↗

Deletion of Socs3 in LysM+ Cells and Cx3cr1 Resulted in Age-dependent Development of Retinal MicrogliopathySemantic proximity Read ↗

Integrins αvβ3 and α4β1 act as coreceptors for fractalkine, and the integrin-binding defective mutant of fractalkine is an antagonist of CX3CR1.Semantic proximity Read ↗

FKN/CX3CR1 Axis Facilitated Migraine-like Behaviors via Activating Thalamic-cortical Network Microglia in SE Rat ModelsSemantic proximity Read ↗

Functional adhesiveness of the CX3CL1 chemokine requires its aggregation. Role of the transmembrane domain.Semantic proximity Read ↗

Microglia undergoes chemokine receptor, CX3CR1-mediated internalization of extracellular TauSemantic proximity Read ↗

The chemokine CX3CL1 (fractalkine) and its receptor CX3CR1: occurrence and potential role in osteoarthritis.Semantic proximity Read ↗

The amino terminus and the third extracellular loop of CX3CR1 contain determinants critical for distinct receptor functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.