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Article

Chemokine receptor mutant CX3CR1-M280 has impaired adhesive function and correlates with protection from cardiovascular disease in humans.

The Journal of clinical investigation - 1 Apr 2003

McDermott David H, Fong Alan M, Yang Qiong, Sechler Joan M, Cupples L Adrienne, Merrell Maya N, Wilson Peter W F, D'Agostino Ralph B, O'Donnell Christopher J, Patel Dhavalkumar D, Murphy Philip M

Abstract excerpt

The chemokine receptor CX3CR1 is a proinflammatory leukocyte receptor specific for the chemokine fractalkine (FKN or CX3CL1). In two retrospective studies, CX3CR1 has been implicated in the pathogenesis of atherosclerotic cardiovascular disease (CVD) based on statistical association of a common receptor variant named CX3CR1-M280 with lower prevalence of atherosclerosis, coronary endothelial dysfunction, and acute...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12697743
DOI: 10.1172/JCI16790
PMCID: PMC152935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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