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Article

Subtle conformational changes between CX3CR1 genetic variants as revealed by resonance energy transfer assays.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2010

Darbandi-Tehrani Kévin, Hermand Patricia, Carvalho Stéphanie, Dorgham Karim, Couvineau Alain, Lacapère Jean-Jacques, Combadière Christophe, Deterre Philippe

Abstract excerpt

The chemokine CX3CL1 is expressed as a membrane protein that forms a potent adhesive pair with its unique receptor CX3CR1. This receptor has 3 natural variants, V249-T280 (VT), I249-T280 (IT), and I249-M280 (IM), whose relative frequencies are significantly associated with the incidence of various inflammatory diseases. To assess the adhesive potency of CX3CR1 and the molecular diversity of its variants, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20667981
DOI: 10.1096/fj.10-156612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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