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Article

The rate and character of spontaneous mutation in Thermus thermophilus.

Genetics - 1 Sept 2008

Mackwan Reena R, Carver Geraldine T, Kissling Grace E, Drake John W, Grogan Dennis W

Abstract excerpt

Selection of spontaneous, loss-of-function mutations at two chromosomal loci (pyrF and pyrE) enabled the first molecular-level analysis of replication fidelity in the extremely thermophilic bacterium Thermus thermophilus. Two different methods yielded similar mutation rates, and mutational spectra determined by sequencing of independent mutants revealed a variety of replication errors distributed throughout the...

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Identifiers

PMID: 18723895
DOI: 10.1534/genetics.108.089086
PMCID: PMC2535672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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