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Article

Rates of Mutations and Transcript Errors in the Foodborne Pathogen Salmonella enterica subsp. enterica.

Molecular biology and evolution - 10 Apr 2022

Pan Jiao, Li Weiyi, Ni Jiahao, Wu Kun, Konigsberg Iain, Rivera Caitlyn E, Tincher Clayton, Gregory Colin, Zhou Xia, Doak Thomas G, Lee Heewook, Wang Yan, Gao Xiang, Lynch Michael, Long Hongan

Abstract excerpt

Because errors at the DNA level power pathogen evolution, a systematic understanding of the rate and molecular spectra of mutations could guide the avoidance and treatment of infectious diseases. We thus accumulated tens of thousands of spontaneous mutations in 768 repeatedly bottlenecked lineages of 18 strains from various geographical sites, temporal spread, and genetic backgrounds. Entailing over ∼1.36 million...

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Identifiers

PMID: 35446958
DOI: 10.1093/molbev/msac081
PMCID: PMC9040049

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