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Article

Loss of genetic accuracy in mutants of the thermoacidophile Sulfolobus acidocaldarius.

Archaea (Vancouver, B.C.) - 1 Mar 2002

Bell Greg D, Grogan Dennis W

Abstract excerpt

To investigate how hyperthermophilic archaea can propagate their genomes accurately, we isolated Sulfolobus acidocaldarius mutants exhibiting abnormally high rates of spontaneous mutation. Our isolation strategy involved enrichment for mutator lineages via alternating selections, followed by screening for the production of spontaneous, 5-fluoro-orotate-resistant mutants in micro-colonies. Several candidates were...

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Identifiers

PMID: 15803658
DOI: 10.1155/2002/516074
PMCID: PMC2685545

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