Loss of genetic accuracy in mutants of the thermoacidophile Sulfolobus acidocaldarius.

doi:10.1155/2002/516074

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Article

Loss of genetic accuracy in mutants of the thermoacidophile Sulfolobus acidocaldarius.

Archaea (Vancouver, B.C.) - 1 Mar 2002

Bell Greg D, Grogan Dennis W

Abstract excerpt

To investigate how hyperthermophilic archaea can propagate their genomes accurately, we isolated Sulfolobus acidocaldarius mutants exhibiting abnormally high rates of spontaneous mutation. Our isolation strategy involved enrichment for mutator lineages via alternating selections, followed by screening for the production of spontaneous, 5-fluoro-orotate-resistant mutants in micro-colonies. Several candidates were...

Topics

Cloning, Molecular
DNA Damage
Genes, Archaeal
Genome, Archaeal
Mutagens
Mutation
Sulfolobus acidocaldarius
Ultraviolet Rays

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Open in PubMed Open full text

Identifiers

PMID: 15803658
DOI: 10.1155/2002/516074
PMCID: PMC2685545

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